Grisanty was born under politically oppressive circumstances in the Dominican Republic. As a child, he spent hours in his grandparents' garden observing colors, textures and lighting. Grisanty wrote: "There, I learned how green is shaded by red. How, without direct light, yellows become brown. How purple unveils its reds and blues in a transparency. And black does not exist. I learned that small things can make a big context and vice versa. I learned that the character of man is as complex as Nature." As a teen, Grisanty studied drawing with Dominican Master Yoryi Morel from 1963–64, studied graphic arts and painting in Mexico City from 1969–1974, and studied interior design at University Pedro Henriquez Ureña in Santo Domingo, Dominican Republic.
From 1974-76, Grisanty designed and directed the Graphic Arts Department Autonoma University in Santo Domingo. At the time he became involved in designing theatrical sets and costumes in Santo Domingo, most notably for the production of Salome, directed by cinematographer Jean Louis Jorge. Grisanty then served as Director for the graphic design department of one of the Dominican Republic's premier advertising agencies, Retho Publicidad in Santo Domingo.
Grisanty moved to Washington, D.C. in 1984 and pursued a career as a painter and graphic artist. He moved to Rehoboth Beach, Delaware in 2004. One year later he co-founded Beach Town Posters, a series of fine art posters celebrating American beach towns, rendered in a vintage Art Deco style. The inspiration for Beach Town Posters came from the French vacation posters that decorated his childhood beach home. Grisanty is the sole artist for the ongoing series.
Grisanty has won a series of awards for his stage and costume design and individual artworks. His notable career achievements include winning the Special Prize from the Jury at the Santo Domingo Art Biennial in 1976, and being declared an "Exceptional Individual of International Renown" during his citizenship process by the U.S. government in 1997.